Stem Cell Therapy for Autism
Table of Contents
Stem Cell Treatment for Autism
According to data provided by the American CDC, autism has progressively become a more common condition among the population in the last 20 years. In order to better comprehend treatment options, understanding first what this condition is imperative. Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours.* Autism is commonly caused by genetics, and sometimes it's also associated with environmental factors, causing alterations in the nerve cells.
Common symptoms of autism are:
- Learning disability
- Speech delay in a child
- Sensitivity to touch, sound or light
- Inappropriate social interaction
- Poor eye contact
- Compulsive behavior
- Repetitive movements
- Persistent repetition of words and actions.
Symptoms usually develop gradually before 3 years old, but some autistic children first develop more normally and then regress.
According to recent information provided by the CDC:
- About 1 in 44 children has been identified with autism spectrum disorder (ASD) according to estimates from CDC’s Autism and Developmental Disabilities Monitoring (ADDM) Network.
- ASD is reported to occur in all racial, ethnic, and socioeconomic groups.
- ASD is more than 4 times more common among boys than among girls.
- About 1 in 6 (17%) children aged 3–17 years were diagnosed with a developmental disability, as reported by parents, during a study period of 2009-2017. These included autism, attention-deficit/hyperactivity disorder, blindness, and cerebral palsy, among others.
Stem Cell Treatment for Autism
With stem cell therapy for autism, the application of mesenchymal stem cells can improve the overall regulation of the immune system and the neural connectivity in the brain. Our milestone is to help children with autism in improving their day to day verbal communication, and social skills also proved to reduce hyperactivity and repetitive behaviors, and boost the immune system.
ASD patients show a decreased number of Purkinje cells in the cerebellum**. These changes could reflect defective cortical organization in ASDs development. In addition, autism is associated with dysregulation in the maturation and plasticity of dendritic spine morphology.***
Restoring injured brain functioning could be achieved by stem-cell-based cell replacement.**** Indeed, transplanted MSCs are able to promote synaptic plasticity and functional recovery and rescue cerebellar Purkinje cells.****** Challenging newest study from Deng et al. suggests that granulocyte colony-stimulating factor (G-CSF) is able to mobilize MSCs into peripheral blood. These mobilized MSCs are incorporated and integrate into damaged brain in craniocerebral injured mice, ameliorating the effect of trauma.*******
It is noteworthy that MSC ability to migrate to the sites of injury and participate in the repair process is a key issue in tissue repair.******** Also by this way, MSC therapy could restore the altered brain organization seen in autistic subjects.
- At least two key-action mechanisms of stem cells could be useful for ASD therapy: paracrine effect (the secretome tool: cytokines, chemokines, and growth factors released by stem cells and responsible of repair/restoration of injured tissues) and immunomodulatory properties. Source
- ASDs show immune system abnormalities and strong proinflammatory cytokine production. Source.
- ASD subjects show an imbalance in innate and adaptive immunity, as CD3+, CD4+, and CD8+ T cells, as well as natural killer (NK) cells, are altered. Source.
- The immune modulatory capacity of stem cells could restore these ASD–immune alterations. Stem cells are able to strongly inhibit CD8+ and CD4+ T lymphocytes and NK cell overactivation and proliferation by inhibiting proinflammatory tumor necrosis factor alpha and interferon gamma molecules and increasing anti-inflammatory IL-10 levels. Source.
What to look forward to
The experiences of Giostar Mexico patients have shown that stem cell therapy can help to improve cognitive function and reduce behavioral symptoms in patients with autism. The therapy works by differentiating stem cells into neurons, which can help to regenerate damaged brain tissue and improve brain function.
Patients who received stem cell therapy reported a significant improvement in their symptoms, including improved cognitive function, improved social interaction, and reduced repetitive behaviors. The therapy has the potential to improve the quality of life of patients with autism and reduce the need for medication. While more research is needed, these results provide hope for those suffering from autism.
Stem cell therapy for Autism cost
Stem cell therapy cost for Autism, in Giostar Mexico, starts at $8,500.00 USD for one application (half-treatment). Pricing highly depends on the personalized protocol that the Medical Director determines based on each patient's condition. What may this include?
- Transportation from hotel-clinic, clinic-hotel and airport-hotel as well as hotel-airport (mainly for our Clinics in Playa del Carmen and Guadalajara; our Clinic in Los Algodones, due to its proximity to the US-Mexico border crossing, we pick up patients on the border or at Yuma Airport and take them to our clinic or their hotel)
- Lodging (available in our Clinic in Algodones) in Hotel Hacienda or Hotel Cielito Lindo
- Oxygen Therapy
- Body preparation – Nutritional IV Therapy
- 1 - 10 billion exosomes (volume depends on Doctor's personal evaluation of each patient)
- 1 - 4 stem cell vials (35 - 140 million stem cells)
- Laboratory protocol by Dr. Anand (activation of the stem cells in order to direct them towards the affected tissue or organ)
- Medical Consultation
- Dietitian Follow up post-therapy
- Preferential prices for future reinforcements/applications
- Laboratory exams the previous day before the first application
If you are interested in receiving the benefits of stem cell therapy, you can fill out this contact form and we will give you a call or email you as soon as possible. You can also contact us directly to our US landline 619-866-6000.
Stem Cell Therapy Financing
Through United Medical Credit, our patients (exclusive for US citizens) may now receive up to $25,000.00 USD in credit for their treatment (note: price for therapy varies depending on the condition to be treated and a number of stem cells [vials] included).
Autism Treatment in Mexico
Being part of the last three decades of innovative discoveries in the research-based area of regenerative medicine, Stem Cell Therapy promotes the reduction and stoppage of degenerative diseases or conditions, such as ALS, physical injuries and aging, bolstering the regeneration of damaged tissues, bodily processes and overall well-being.
Giostar Mexico specializes in medical tourism, receiving patients from all over the world. With the acquired understanding based on scientific research, we are able to provide personalized protocols to each patient. Through specialized allogenic mesenchymal adult stem cells, our regenerative therapy concentrates stem cells in the targeted area, organ or immune system, helping the body stop the progression of a disease or condition and begin regeneration.
Why choose Giostar?
Thanks to a progressive legal framework in Mexico, Giostar can provide personalized therapy with intravenous and local applications otherwise legally unavailable in the United States and Canada. As everyone is unique, we develop personalized protocols for each patient. Although patients may share the same condition, we understand that similar symptoms does not necessarily mean same solution or treatment for everyone. Genetics, lifestyle and other circumstances can affect differently how patients respond to therapy.
It’s of utmost importance that you answer our health history form, this will determine two major factors:
- Your eligibility for therapy
- Your personalized protocol is developed according to your needs.
Stem cell therapy is a procedure in the regenerative medicine field. Regenerative medicine's ultimate goal is that our body regenerates itself. What stem cell therapy does in your body is slow down or stop the suffered deterioration and it can even regenerate damaged tissue and organs. That is why we ask our patients to fill out a Health Form, so our medical staff may first identify if stem cell therapy is actually an option for them, as well as allowing our medical team to understand each patient's specific health conditions.
Stem Cell Therapy for Autism Research References
* Dario Siniscalco, Anna Sapone, Alessandra Cirillo, Catia Giordano, Sabatino Maione, Nicola Antonucci, "Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?", BioMed Research International, vol. 2012, Article ID 480289, 6 pages, 2012. https://doi.org/10.1155/2012/480289
** M. L. Bauman and T. L. Kemper, “Neuroanatomic observations of the brain in autism: a review and future directions,” International Journal of Developmental Neuroscience, vol. 23, no. 2-3, pp. 183–187, 2005.
*** D. A. Fortin, T. Srivastava, and T. R. Soderling, “Structural modulation of dendritic spines during synaptic plasticity,” Neuroscientist. In press.
**** A. T. Sørensen, N. Rogelius, C. Lundberg, and M. Kokaia, “Activity-dependent long-term plasticity of afferent synapses on grafted stem/progenitor cell-derived neurons,” Experimental Neurology, vol. 229, no. 2, pp. 274–281, 2011.
******R. C. Rodrigues Hell, M. M. Silva Costa, A. M. Goes, and A. L. Oliveira, “Local injection of BDNF producing mesenchymal stem cells increases neuronal survival and synaptic stability following ventral root avulsion,” Neurobiology of Disease, vol. 33, no. 2, pp. 290–300, 2009.
******* J. Deng, Z. M. Zou, T. L. Zhou et al., “Bone marrow mesenchymal stem cells can be mobilized into peripheral blood by G-CSF in vivo and integrate into traumatically injured cerebral tissue,” Neurological Sciences, vol. 32, no. 4, pp. 641–651, 2011.
******** L. Li and J. Jiang, “Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms,” Frontier Medical, vol. 5, pp. 33–39, 2011.